The virus is spreading again, and this time, it’s personal. The first official trailer for Resident Evil (2025) has just been released, offering a spine-chilling new vision of the beloved horror franchise, now with Leonardo DiCaprio and Angelina Jolie at the helm of the action.

Directed by David Fincher (Gone Girl, Seven), this reboot takes the Resident Evil series back to its roots, diving deep into the origins of the T-virus outbreak. DiCaprio plays John Reese, a brilliant but tormented biochemist who uncovers the dark secrets behind the Umbrella Corporation. Jolie stars as Elena Miller, a hardened former soldier who has spent years hunting down the remnants of Umbrella’s research—only to realize that their latest experiment has gone far beyond their control.

The teaser opens with an eerie, abandoned Raccoon City skyline as DiCaprio’s John races against the clock, trying to decipher a biological code that could stop the outbreak. His voiceover says: “The virus didn’t start in a lab. It started with something far worse.”

Key moments in the trailer include:

• DiCaprio’s character discovering the horrifying extent of Umbrella’s experiments on human and animal subjects, leading to the creation of grotesque new bio-creatures

• A heart-pounding escape sequence with Jolie’s Elena, as she battles a horde of mutated zombies and mutated creatures in a blood-soaked laboratory

• Tense, suspenseful confrontations between the main characters and an unknown, masked villain who seems to control the virus’s spread

• DiCaprio and Jolie teaming up to infiltrate an Umbrella research facility, with explosions, gunfire, and sinister lab experiments in the backdrop

• A terrifying glimpse of Nemesis, an iconic antagonist in the Resident Evil lore, now reimagined with cutting-edge visual effects

The trailer sets a dark, ominous tone, with Fincher’s signature suspenseful pacing and psychological tension blending perfectly with the action-heavy sequences. The new take promises not just zombies, but a deeper exploration of conspiracy, betrayal, and the human cost of scientific hubris.

Fans are already buzzing on social media, with hashtags like #ResidentEvil2025, #DiCaprioAndJolie, and #TvirusReturns flooding the platforms.

Resident Evil (2025) will hit theaters on October 3, 2025, just in time for the Halloween season.

The virus never forgets. The truth is coming for us all. And survival is just the beginning. 🧟‍♂️🔬